4-METHOXY-5-(3-MORPHOLINOPROPOXY) -2-NITROBENZONITRILE

Name	Benzonitrile,4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro-
Synonyms	Gefitinib PI-1 Gefitinib Intermediate 1 2-Nitro-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile 4-Methoxy-2-nitro-5-(3-Morpholinopropoxy)benzonitrile Benzonitrile,4-Methoxy-5-[3-(4-Morpholinyl)propoxy]-2-nitro- Benzonitrile,4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro- 4-METHOXY-5-(3-MORPHOLINOPROPOXY) -2-NITROBENZONITRILE _675126-26-8 4-Methoxy-5-(3-Morpholinopropoxy)-2-Nitrobenzonitrile Gefitinib HCL InterMediates G4
CAS	675126-26-8
EINECS	1806241-263-5

Molecular Formula	C15H19N3O5
Molar Mass	321.33
Density	1.29
Melting Point	127℃
Boling Point	522.3±50.0 °C(Predicted)
pKa	6.96±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature

biological activity	Gefitinib importance 1 is an impurity of Gefitinib. Gefitinib is a potent, orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 54 nM) and blocks EGFR autophosphorylation in EGF-stimulated tumor cells. Gefitinib can also induce autophagy in cells. Gefitinib has anti-tumor activity.
Use	gefitinib intermediate

Last Update：2024-04-09 02:00:10

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